08:00 – 08:30 am

Registration: Main Lobby, Hotel Champlain

08:00 – 10:00 am

Breakfast: Foyer outside Green Mountain Room B & C

08:30 – 08:50 am

Welcome: Ofer Levy, MD, PhD (Precision Vaccines Program, Boston Children’s Hospital & Harvard Medical School)

08:50 – 09:35 am

Keynote Speaker: Jessica Lasky-Su, DSc, MS (Brigham and Women’s Hospital), From Viral Mimicry to Multimorbidity: Antibody Profiles as Precision Biomarkers of Aging and Disease

09:35 – 10:00 am

Coffee Break

Session 1: Emerging And Re-Emerging Diseases And Challenges

10:00 – 10:15 am

Targeted Defense: Tailoring Respiratory Syncytial Virus Protection For Every Age, Bukky Idoko, PhD (Sanofi)

10:15 – 10:30 am

Updates on Dengue Vaccines, Beth Kirkpatrick, MD (University of Vermont)

10:30 – 10:45 am

A Lung Time Coming: Insights Into Markers Of Vaccine-Mediated Protection From Tuberculosis, Margie Ackerman, PhD (Dartmouth College)

10:45 – 11:00 am

Q&A Panel

Session 2: Preclinical Modeling Of Vaccine Action

11:00 – 11:15 am

Unlocking Immunity: The Adjuvant AS01 As A Key To Vaccinate Diverse Populations, Margherita Coccia, DPhil (GlaxoSmithKline)

11:15 – 11:30 am

Deep Phenomics Of Human Innate And Adaptive Responses, Soumik Barman, PhD (Precision Vaccines Program, Boston Children’s Hospital & Harvard Medical School)

11:30 – 11:45 am

Development Of A Microphysiological Human In Vitro Model For Vaccine Assessment, Guzman Sanchez-Schmitz, PhD (Precision Vaccines Program, Boston Children’s Hospital & Harvard Medical School)

11:45 – 12:00 pm

Mining The CD4 Antigen Repertoire Or Next-Generation Tuberculosis Vaccines, Dan Barouch, MD, PhD (Beth Israel Deaconess Medical Center & Harvard Medical School)

12:00 – 12:15 pm

Q&A Panel

12:15 – 1:45 pm

Free time to enjoy lunch at your leisure.

• August First Bakery
• Skinny Pancake
• American Flatbread
• Vermont Pub & Brewery

1:45 – 2:15 pm

Grab and Go Snacks: Foyer outside Green Mountain B & C

Session 3: Vaccine Safety

2:00 – 2:15 pm

Immunization Safety: From Risk Assessment To Risk Reduction, Robert Chen, MD (Brighton Collaboration & INSIS)

2:15 – 2:30 pm

International Network Of Special Immunization Services: Harnessing Precision Vaccinology To Advance Vaccine Safety Science, Karina Top, MD (University of Alberta & INSIS)

2:30 – 2:45 pm

Vaccine Safety: Assessing And Communicating Risks, Al Ozonoff, PhD (Broad Institute at Massachusetts Institute of Technology & Boston Children’s Hospital)

2:45 – 3:00 pm

Q&A Panel

Session 4: Systems Vaccinology

3:00 – 3:15 pm

The Immune Signatures Data Resource: An AI-Ready Compendium of Systems Vaccinology Datasets, Joann Arce, PhD (Precision Vaccines Program, Boston Children’s Hospital & Harvard Medical School)

3:15 – 3:30 pm

Live Attenuated Tetravalent Dengue Vaccination Generates Durable Immune Memory Responses For At Least A Decade In Dengue-Naïve Adult Recipients, Sean Diehl, PhD (University of Vermont)

3:30 – 3:45 pm

Identifying Molecular Correlates of Vaccine Response in Newborns, Casey Shannon, PhD (University of British Columbia)

3:45 – 4:00 pm

Q&A Panel

4:00 – 4:15 pm

Oral Abstract Presentation: Integrative Mapping Of Pre-Existing Influenza Immune Landscapes Predicts Vaccine Response, Adriana Tomic, PhD (Boston University)

4:15 – 4:30 pm

Oral Abstract Presentation: Safety and Immunogenicity of PanChol: A Single-Dose Live Attenuated Oral Cholera Vaccine Candidate, Deborah R. Leitner, PhD (Brigham and Women’s Hospital)

4:30 – 4:40 pm

Closing Remarks: Kristen Pierce, MD (University of Vermont)

5:00 – 5:05 pm

Meet promptly in the lobby to walk to dinner

5:30 – 7:30 pm

Dinner cruise on the Spirit of Ethan Allen

08:00 – 08:05 am

Opening Remarks

08:05 – 08:50 am

Keynote Speaker: Paolo Palma, MD, PhD (Ospedale Pediatrico Bambino Gesu & Vaccinopolis), Pediatric HIV And The Search For An Effective Immunotherapeutic Strategy

Session 5: Clinical Vaccinology

08:50 – 09:05 am

Leveraging Trained Immunity To Optimize Pediatric Vaccination, Asimenia Angelidou, MD, PhD (Precision Vaccines Program, Boston Children’s Hospital & Harvard Medical School, Beth Israel Deaconess Medical Center)

09:05 – 09:20 am

Dengue Vaccines, Kristen Pierce, MD (University of Vermont)

09:20 – 09:35 am

Molecular Signatures At Baseline and Post-Vaccine Predict Humoral Immunogenicity Of A GLA-SE Adjuvanted gp120 HIV Vaccine In Infants, Kinga Smolen, PhD (Precision Vaccines Program, Boston Children’s Hospital & Harvard Medical School)

09:35 – 09:50 am

Q&A Panel

09:50 – 10:05 am

Oral Abstract Presentation: Discovery Of A Small Molecule TLR3 Agonist Adjuvant, John Mark Awad, PhD & Kimia Abedi, BS (Precision Vaccines Program & Boston Children’s Hospital)

10:05 – 10:20 am

Oral Abstract Presentation: Hybrid Flagellin-Hepatitis B Virus-like Particle And mRNA-based Universal Influenza Vaccines, Labone Akter, PhD (Student, University of Rhode Island)

10:20 - 11:20 am Coffee Break, Poster Presentations, and Exhibits

Session 6: Implications Of Population Trajectory On Precision Vaccinology

11:20 – 11:35 am

Aging And Vaccinology, Amy Sherman, MD (Brigham And Women’s Hospital)

11:35 – 11:50 am

A tale of Two pathogens: Differing Challenges With Vaccine Response, Lindsey Baden, MD (Brigham And Women’s Hospital)

11:50 am – 12:00 pm

Q&A Panel

Lunch and Free Time

12:00 – 3:00 pm

Free time to explore Burlington and enjoy lunch at your leisure.

Panel Discussion

2:45 – 3:15 pm

Grab and go snacks available outside the conference room

3:00 – 4:00 pm

Vaccines At A Crossroads: Considerations & Path Forward

Session 7: Adjuvants

4:00 – 4:15 pm

Human In Vitro Modeling Platforms For The Preclinical Investigation Of Adjuvant Combinations, Simon Van Haren, PhD (Precision Vaccines Program, Boston Children’s Hospital & Harvard Medical School)

4:15 – 4:30 pm

Functionalization Of Endosomal-Targeting Small Molecule Agonist Adjuvants For Precision Immune Response, Morgan Goetz, PhD (Precision Vaccines Program, Boston Children’s Hospital & Harvard Medical School)

4:30 – 4:45 pm

IL-12-MOP And GM-CSF-MOP Biological mRNA-LNP Adjuvants Amplify Influenza-Specific Immunity When Admixed With Recombinant Hemagglutinin Antigens, Byron Brook, PhD (Precision Vaccines Program, Boston Children’s Hospital & Harvard Medical School)

4:45 – 5:00 pm

Adjuvants: Bridging The Gap Between Innate and Adaptive Immunity, Jay Evans, PhD (Inimmune Inc)

5:00 – 5:15 pm

Q&A Panel

5:15 – 5:25 pm

Coffee Break

5:25 – 5:40 pm

Oral Abstract Presentation: Pre-Vaccination Immune Signatures of Children with Inborn Errors of Immunity Associated with BNT162B2 mRNA COVID-19 Vaccine Response, Donato Amodio MD, PhD (Ospedale Pediatrico Bambino Gesu)

5:40 – 5:55 pm

Oral Abstract Presentation: Molecular Deconvolution of Maternal Systemic and Mucosal Antibody Repertoires Transferred To The Neonate, Lowrey Peyton, BS (Dartmouth College)

Session 8: Addressing The Opioid Epidemic With Vaccines

5:55 – 6:10 pm

Prescription Opioid Exposure and Overdose Risk, Sharon Levy, MD, MPH (Boston Children’s Hospital & Harvard Medical School)

6:10 – 6:25 pm

Attitudes Towards An Opioid Vaccine, Elissa Weitzman, ScD, MSc (Boston Children’s Hospital)

6:25 – 6:40 pm

Mucosal Vaccine Protection Against Fentanyl Intoxication Generates Meningeal Plasma Cells and Requires IgA., Elizabeth "Betzi" Norton, PhD (Tulane University)

6:40 – 6:55 pm

Q&A Panel

6:55 – 7:10 pm

Closing Remarks, Paolo Palma, MD, PhD